D09 : In Silico Design of a PD-1/TCR Bispecific T-Cell Engager for Immunotherapy in T-Cell Malignancies
| Students | Krishangi Oberoi
|
| School | HDSB - Abbey Park High School - Oakville |
| Level | Senior 11/12 - Grade 11 |
| Group | Group 12 - Health Science IV |
| Abstract | The purpose of this project was to design a PD-1/TCR bispecific T-cell engager (BiTE), a molecular bridge connecting two immune targets, to identify antibody candidates capable of binding PD-1 on malignant T-cells and TCR on cytotoxic T-cells. By enabling cytotoxic T-cells to directly engage and attack tumor cells, this approach aims to improve immunotherapy precision for aggressive T-cell malignancies where treatment options remain limited. |