E04 : Engineering a Smart Probiotic-Based Drug Delivery Device for Gut–Lung Axis Targeted Immunotherapy


Students Renee Ren
School IND - Appleby College - Oakville
Level Intermediate 9/10 - Grade 10
Group Group 9 - Health Sciences II
Abstract This project’s purpose is to build a device that enables targeted gut-lung axis immunotherapy for lung cancer. The engineered system is designed to detect kynurenine-associated immune suppression signals and trigger controlled production of anti–PD-L1 nanobody therapy within the gut microbiome. A built-in biosafety lysis mechanism is included to ensure biocontainment and prevent uncontrolled bacterial persistence.