E05 : Improving PDAC Prognosis: Novel Approach Utilising CRISPR-Mediated Gene Knockout for TME Disruption
| Students | Siqi Tan
Yuewen Li |
| School | HDSB - W. H. Morden Public School - Oakville |
| Level | Junior 7/8 - Grade 8 |
| Group | Group 4 - Health Sciences III |
| Abstract | Pancreatic ductal adenocarcinoma, characterised by a suppressive tumour microenvironment (TME), is associated with dismal survival rates and limited treatment options. Our proposal is to leverage CRISPR-Cas9 technology to disrupt the immunosuppressive TME through gene knockout of associated protein. This novel strategy can improve efficacy when combined with conventional treatments, as well as allowing for a more targeted and adaptable model to traditional inhibitory drug development. |
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