Q03 : Computational Sequence-Based Prediction of Creutzfeldt-Jakob Disease with NSPDI-SNN AI Framework
| Students | Jordan LeBlanc
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| School | HDSB - Abbey Park High School - Oakville |
| Level | Intermediate 9/10 - Grade 9 |
| Group | Group 12 - Health Science IV |
| Abstract | Prion protein misfolding causes Creutzfeldt-Jakob Disease (CJD), a fatal neurodegenerative disorder. However, experimentally testing the pathogenicity of PRNP variants is time-consuming, costly, and complex. This project uses a nonlinear synaptic pruning and dendritic integration transformer-based machine learning model (NSPDI-SNN) to predict which prion protein sequences misfold. The approach demonstrates how computational modeling can provide a fast, interpretable tool for studying disease-associated protein variants. |
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