E12 : NeuroRegen: A Novel Dual-Action Intranasal Nanoparticle Treatment for Alzheimer’s Disease
| Students | Rahul Rao
Vivaan Kar |
| School | HDSB - White Oaks Secondary School - Oakville |
| Level | Intermediate 9/10 - Grade 9 |
| Group | Group 9 - Health Sciences II |
| Abstract | Over 55 million people worldwide are currently living with Alzheimer’s disease, a number projected to double by 2050. Despite its prevalence, existing treatments such as Donepezil and Memantine primarily alleviate symptoms rather than targeting the underlying neurodegeneration or have extreme side effects with limited efficacy. This project proposes a dual-action therapeutic treatment combining Tropoflavin, a TrkB receptor agonist, and EF24, a tau regulating curcumin analog, delivered intranasally via nanoparticles to enhance brain delivery and therapeutic efficacy. |